5-Amino-1MQ (NNMT Inhibitor) Peptide Information
- Chemical Name: 5-Amino-1-methylquinolinium (5-Amino-1MQ)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 5mg and 10mg variants
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
5-Amino-1MQ is a small, selective membrane-permeable molecule that functions as an inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). It is currently a subject of significant interest in metabolic research, specifically regarding the regulation of energy expenditure and adipose tissue physiology.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, 5-Amino-1MQ is utilized to study the pathways of cellular metabolism. The primary target of this compound, the NNMT enzyme, is predominantly expressed in adipose (fat) tissue and the liver.
Research indicates that NNMT plays a role in processing Vitamin B3 (nicotinamide). When NNMT is active, it methylates nicotinamide, which can lead to a reduction in cellular NAD+ (Nicotinamide Adenine Dinucleotide) levels. By introducing 5-Amino-1MQ in controlled experimental models, researchers have observed the following biochemical interactions:
- Inhibition of NNMT: The compound effectively blocks the enzymatic activity of NNMT.
- NAD+ Modulation: Studies suggest that inhibiting NNMT supports higher intracellular concentrations of NAD+, a coenzyme critical for mitochondrial function and cellular energy metabolism.
- Sirtuin Activation: Elevated NAD+ levels are linked to the activation of Sirtuin-1 (SIRT1), a protein involved in cellular health and metabolic regulation.
Quality and Purity
We are committed to providing researchers with the highest quality materials for reliable data collection. This peptide is manufactured under strict laboratory conditions to ensure structural integrity and stability.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For further reading on the biochemical properties and research studies regarding 5-Amino-1MQ, please refer to the following literature:
Nature Medicine (2014) – Study on NNMT inhibition in adipose tissue. click here to view the article
Scientific Reports (2021) – Research regarding NNMT inhibition and muscle function in aged mice. click here to view the article
Biochemical Pharmacology (2018) – Analysis of 5-Amino-1MQ as a selective NNMT inhibitor. click here to view the article
