HGH Fragment 176-191 Peptide Information
- Chemical Name: Human Growth Hormone Fragment 176-191 (Tyr-hGH177-191)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 2mg, 5mg, 10mg, 12mg & 15mg variants
- Inclusions: Includes 1 x 3ml or 1 x 10ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
HGH Fragment 176-191 is a synthetic peptide corresponding to the C-terminal amino acid residues 176 through 191 of the human growth hormone (HGH) molecule. Researchers isolate this specific region because it acts as the primary lipolytic domain of the full-length hormone.
Unlike the full HGH molecule (191 amino acids), this fragment lacks the molecular domain responsible for binding to the growth hormone receptor involved in insulin-like growth factor 1 (IGF-1) secretion. This unique characteristic makes it a critical tool for isolating metabolic effects from growth-promoting effects in laboratory studies.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, HGH Fragment 176-191 is utilized to study adipose tissue physiology and lipid metabolism. It allows researchers to investigate the pathways of fat breakdown without the confounding variables of glycemic control or cell proliferation associated with full-length HGH.
Key areas of biochemical investigation include:
- Lipolysis Stimulation: The peptide is studied for its ability to stimulate lipolysis (the breakdown of lipids) in adipose tissue.
- Inhibition of Lipogenesis: Research indicates the fragment may inhibit lipogenesis, the metabolic process of converting non-fat precursors into fatty acids.
- Beta-Adrenergic Receptors: Studies explore the peptide’s interaction with beta-3 adrenergic receptors (ADRB3), which play a significant role in the regulation of thermogenesis and lipolysis in white and brown adipose tissues.
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the biochemical properties, lipolytic activity, and experimental studies regarding the C-terminal fragment of HGH, please refer to the following literature:
Journal of Endocrinology (2001) – Investigation into the metabolic effects of the C-terminal region of HGH. click here to view the article
Acta Physiologica Scandinavica (1998) – Study regarding the lipid-mobilizing activity of growth hormone fragments. click here to view the article
Hormone Research (2000) – Research comparing the metabolic actions of hGH and its fragments in laboratory models. click here to view the article
