IGF-1 LR3 (Long R3 IGF-1) | 10 x 100mcg Kit Peptide Information
- Chemical Name: Long Arg3 Insulin-like Growth Factor-1 (IGF-1 LR3)
- Format: 10 x Lyophilised Powder Vials (Kit Format)
- Concentration: 100mcg per vial (Total 1mg per kit)
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
This research kit contains 10 individual vials of IGF-1 LR3, each containing 100mcg of lyophilised peptide. IGF-1 LR3 is a synthetic analog of human Insulin-like Growth Factor-1, modified with an Arginine substitution at position 3 and a 13-amino acid N-terminal extension.1
Advantage of Kit Format:
The 10 x 100mcg configuration is specifically designed for laboratory applications requiring multiple, separate experimental runs. By aliquoting the peptide into smaller quantities, researchers can reconstitute single vials as needed. This minimizes the degradation often associated with repeated freeze-thaw cycles or long-term storage of reconstituted peptides, ensuring maximum stability and data integrity for each experiment.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, IGF-1 LR3 is utilized to study cellular proliferation, survival, and protein synthesis. The structural modifications of the peptide significantly reduce its affinity for Insulin-like Growth Factor Binding Proteins (IGFBPs), allowing for more potent bioactivity in cell culture compared to native IGF-1.
Key areas of biochemical investigation include:
- Cell Culture Stability: The 100mcg aliquot size is ideal for single-use cell culture treatments, preventing peptide aggregation and loss of potency.
- Signaling Cascades: Used to stimulate and map the PI3K/Akt and MAPK/ERK pathways in various cell lines.
- Differentiation Studies: Researchers utilize this specific analog to induce differentiation in myoblasts and osteoblasts without the interference of endogenous binding proteins found in serum.
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).2
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight. Unreconstituted vials should be kept frozen for long-term storage.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the structural modifications, binding protein interactions, and biological activity of IGF-1 LR3, please refer to the following literature:
Journal of Molecular Endocrinology (2000) – Study on the reduced affinity of IGF-1 analogs for binding proteins. click here to view the article
Experimental Cell Research (1994) – Research regarding the biological potency of Long R3 IGF-1 in cell culture. click here to view the article
Biochemical Journal (1998) – Investigation into the signaling pathways activated by IGF-1 variants. click here to view the article
