NAD+ (Nicotinamide Adenine Dinucleotide) Coenzyme Oxidized Form Information
- Chemical Name: Nicotinamide Adenine Dinucleotide (Oxidized form)
- Abbreviation: NAD+ / NAD
- Format: Lyophilised Powder (Amber Vial)
- Concentration: Available in 250mg, 500mg, and 1000mg variants
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution) for 250mg or 1 x 10ml Bacteriostatic Water for 500mg & 1000mg.
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview NAD+ (Nicotinamide Adenine Dinucleotide) is a central coenzyme found in all living cells. It consists of two nucleotides joined through their phosphate groups: one nucleotide contains an adenine base and the other nicotinamide. It is essential for transferring electrons from one reaction to another.
Light Sensitivity Protection: Please note that this product is supplied in specialized amber (brown) glass vials. NAD+ is a photosensitive compound and degrades rapidly upon exposure to UV and visible light. The amber glass provides a necessary protective barrier to maintain the structural integrity and potency of the coenzyme during storage and shipping.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications In laboratory settings, NAD+ is a fundamental reagent used to investigate cellular metabolism and enzymatic regulation. It serves as a critical cofactor in redox reactions and as a substrate for various enzyme families.
Researchers utilising this compound in controlled experimental models investigate the following biological mechanisms:
- Redox Cofactor: NAD+ acts as an electron carrier, accepting electrons to become NADH. This conversion is the primary focus of research into glycolysis, the citric acid cycle (Krebs cycle), and oxidative phosphorylation in mitochondria.
- Sirtuin Activation: NAD+ is the obligatory substrate for Sirtuins (SIRT1–SIRT7), a class of proteins involved in regulating cellular homeostasis, gene silencing, and DNA repair.
- DNA Repair: It is utilized in studies involving Poly (ADP-ribose) polymerases (PARPs), enzymes that consume NAD+ to detect and repair DNA damage within the nucleus.
Quality and Purity We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dark place. Protect from light at all times.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the metabolic role, enzymatic interactions, and biochemical properties of NAD+, please refer to the following literature:
Trends in Biochemical Sciences (2014) – Review of NAD+ metabolism and its regulation of cellular processes. click here to view the article
Cell Metabolism (2018) – Investigation into the role of NAD+ as a signaling molecule and substrate for Sirtuins. click here to view the article
Journal of Biological Chemistry (2005) – Study detailing the kinetics of PARP-1 activity and NAD+ consumption. click here to view the article