PEG-MGF (Pegylated Mechano Growth Factor) Peptide Information
- Chemical Name: Pegylated Mechano Growth Factor (PEG-IGF-1Ec)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 2mg & 10mg vial
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
PEG-MGF is a synthetic form of Mechano Growth Factor (MGF), a splice variant of the IGF-1 gene. This variant is chemically modified through a process called PEGylation, where a Polyethylene Glycol (PEG) chain is attached to the peptide structure.
In standard MGF, the peptide is rapidly broken down by enzymes in the blood, limiting its activity to the local tissue where it is expressed. The addition of the PEG group acts as a protective shell, shielding the peptide from enzymatic degradation. This modification significantly increases the plasma half-life of the compound, allowing for systemic circulation in experimental models.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, PEG-MGF is utilized to study the systemic effects of the MGF splice variant, contrasting with the localized effects of standard MGF.
Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:
- Pharmacokinetics and Stability: Research focuses on the enhanced stability provided by the PEGylation process, comparing the clearance rates and half-life of PEG-MGF versus non-pegylated MGF in plasma.
- Satellite Cell Proliferation: Like its parent compound, PEG-MGF is used to investigate the activation of satellite cells (myogenic stem cells) and their entry into the cell cycle, a precursor to myogenesis.
- Systemic Distribution: The compound allows researchers to study MGF receptor signaling in tissues that are not the primary site of administration, testing the hypothesis of systemic transport efficiency.
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on peptide PEGylation, stability mechanics, and experimental studies regarding MGF, please refer to the following literature:
Journal of Endocrinology (2010) – Study on the stability and bioactivity of pegylated IGF-1 variants. click here to view the article
Basic & Clinical Pharmacology & Toxicology (2009) – Research regarding the effects of MGF on satellite cell proliferation in vitro. click here to view the article
Molecular Therapy (2008) – Investigation into the signaling pathways of MGF splice variants and their role in cell survival. click here to view the article
