Epitalon (Epithalon) | 10mg & 50mg
Technical Specifications
- Sequence: Ala-Glu-Asp-Gly (AEDG)
- Chemical Name: Synthetic Tetrapeptide (Epithalamin Analogue)
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Endotoxin: <0.5 EU/mg (Suitable for sensitive in vitro assays)
- Solubility: High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 10mg Vial: Contains 10mg Epitalon (Epithalon)
- 50mg Vial: Contains 50mg Epitalon (Epithalon) – High Concentration Research Vial
Product Overview
Epitalon (also known as Epithalon) is a synthetic tetrapeptide consisting of four amino acids (Alanine-Glutamate-Aspartate-Glycine). It is a structural analogue of Epithalamin, a polypeptide naturally secreted by the pineal gland.
This peptide is a primary reagent in the field of gerontology (aging research). Unlike general antioxidants, Epitalon is investigated for its specific ability to induce telomerase activity in somatic cells. By upregulating the expression of the catalytic subunit of telomerase, Epitalon is used in laboratory models to study the elongation of telomeres—the protective caps at the ends of chromosomes that shorten with cellular division and age.
The 50mg High-Concentration Variant is specifically designed for laboratories conducting extended longitudinal studies or high-volume cell culture assays where larger stock solutions are required.
Quality Assurance
This compound has undergone rigorous third-party analysis to ensure it meets the highest standards for laboratory use.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 390.3 g/mol) and amino acid sequence.
- TFA Removal: Processed via acetate exchange to remove inflammatory trifluoroacetic acid salts, ensuring high viability in sensitive cell culture applications.
Research Mechanism
In laboratory settings, Epitalon is utilised to investigate:
- Telomere Elongation: The mechanism by which the peptide reactivates the telomerase enzyme in fibroblasts and lymphocytes, potentially delaying the "Hayflick Limit" (cellular senescence).
- Circadian Regulation: The peptide's influence on the pineal gland and its ability to normalise melatonin secretion and circadian rhythms in aged animal models.
- Antioxidant Capacity: Research into the peptide's ability to inhibit lipid peroxidation and increase the activity of endogenous antioxidant enzymes (SOD, Glutathione Peroxidase).
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, diagnostic, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE) including gloves and safety eyewear.
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Biogerontology (2003) – "Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells." (The landmark study on telomeres). View Article
Neuro Endocrinology Letters (2001) – "Peptides of pineal gland and consequences of their application in organism aging." View Article
Advances in Gerontology (2014) – "Peptide geroprotectors from the pituitary and pineal gland." Review of the mechanism of action. View Article
