IGF-1 LR3 (Long R3 IGF-1) Peptide Information
- Chemical Name: Long Arg3 Insulin-like Growth Factor-1 (IGF-1 LR3)
- Format: Lyophilised Powder (Vial)1
- Concentration: Available in 1mg vial
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)2
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
IGF-1 LR3 is a synthetic analog of the naturally occurring human Insulin-like Growth Factor-1 (IGF-1).3 It differs from the native protein due to the substitution of Glutamic acid with Arginine at position 3, along with a 13-amino acid extension at the N-terminus.
This structural modification drastically reduces the peptide's affinity for Insulin-like Growth Factor Binding Proteins (IGFBPs). In native biological systems, IGFBPs bind to IGF-1 and inhibit its biological actions. By avoiding this binding, IGF-1 LR3 exhibits a significantly prolonged half-life and increased potency in laboratory assays compared to standard IGF-1.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, IGF-1 LR3 is a critical reagent for studying cell cycle progression and cellular differentiation. It is widely used in cell culture applications to induce cell survival and proliferation without the interference of binding proteins.
Key areas of biochemical investigation include:
- Signaling Pathways: The peptide is used to map the activation of the PI3K/Akt (cell survival) and MAPK/ERK (cell proliferation) signaling cascades.
- Myogenesis: Researchers utilize IGF-1 LR3 to study the differentiation of myoblasts into myotubes and the regulation of muscle protein synthesis rates in tissue samples.
- Glucose Transport: Studies investigate the peptide's ability to stimulate glucose uptake in cells via the translocation of GLUT4 transporters, independent of insulin signaling.
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the structural modifications, binding protein interactions, and biological activity of IGF-1 LR3, please refer to the following literature:
Journal of Molecular Endocrinology (2000) – Study on the reduced affinity of IGF-1 analogs for binding proteins. click here to view the article
Experimental Cell Research (1994) – Research regarding the biological potency of Long R3 IGF-1 in cell culture. click here to view the article
Biochemical Journal (1998) – Investigation into the signaling pathways activated by IGF-1 variants. click here to view the article
