MOTS-c (Mitochondrial-Derived Peptide) | 10mg & 40mg
Technical Specifications
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Yys-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (16 Amino Acids)
- Chemical Class: Mitochondrial-Derived Peptide (MDP)
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Endotoxin: <0.5 EU/mg (Suitable for sensitive in vitro assays)
- Solubility: Moderate (High concentration may require patience)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 10mg Vial: Standard research aliquot.
- 40mg Vial: High-Concentration Vial. Note: This vial contains a dense peptide cake.
Product Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded within the mitochondrial genome, rather than the nuclear genome.
It is classified as a "mitochondrial-derived peptide" (MDP) and has emerged as a critical signaling molecule involved in metabolic regulation. Research indicates that MOTS-c targets skeletal muscle and acts as an exercise mimetic at the cellular level. It functions by translocating to the nucleus in response to metabolic stress, where it interacts with the folate cycle and the AMPK pathway (Adenosine Monophosphate-Activated Protein Kinase).
This unique mechanism makes MOTS-c a primary reagent for investigating metabolic flexibility, insulin sensitivity, and the prevention of age-related metabolic decline.
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 2174.6 Da).
- Solubility Testing: Verified for dissolution characteristics in bacteriostatic water (see Technical Data for handling instructions).
Research Mechanism
In laboratory settings, MOTS-c is utilised to investigate:
- AMPK Activation: The pathway by which MOTS-c increases glucose uptake and fatty acid oxidation in muscle cells, mimicking the effects of aerobic exercise.
- Folate Cycle Interaction: How the peptide regulates de novo purine biosynthesis by inhibiting the folate cycle (specifically targeting AICAR transformylase).
- Metabolic Homeostasis: Studies examining the prevention of diet-induced obesity and insulin resistance in high-fat diet models.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, weight loss, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE).
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Cell Metabolism (2015) – "The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance." (The seminal discovery paper by Dr. Cohen/Lee). View Article
Journal of Molecular Medicine (2018) – "MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism." View Article
Nature Communications (2021) – "MOTS-c attenuates age-dependent physical decline in skeletal muscle." (Research on aging and physical performance). View Article
Aging (Albany NY) (2016) – "Mitochondrial-derived peptide MOTS-c: effects on metabolic profiles and cell differentiation." View Article
