Product Overview
NAD+ (Nicotinamide Adenine Dinucleotide) | 250mg, 500mg & 1000mg (1g)
NAD+ is not a peptide, but a critical coenzyme found in every living cell. It is the central catalyst of metabolism, responsible for transferring electrons in the Krebs cycle to generate ATP (cellular energy).
The "Direct" Advantage:
Unlike popular precursors such as NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which require enzymatic conversion by the liver to become active, Lyophilised NAD+ provides the direct, bioactive coenzyme. This bypasses the rate-limiting enzyme NAMPT, levels of which naturally decline in aging research models.
Stability & Purity:
NAD+ is notoriously unstable in liquid form, rapidly degrading into Nicotinamide. This product is Lyophilised (Freeze-Dried), ensuring the molecule remains intact and potent until the moment of reconstitution. It is the gold-standard reagent for investigating Sirtuin activation (longevity genes), DNA repair via PARP enzymes, and the restoration of mitochondrial function in hypoxic or aged tissue.
Technical Specifications
- Chemical Formula: $C_{21}H_{27}N_{7}O_{14}P_{2}$
- Format: Lyophilised Cake/Powder (Stabilised)
- Purity: >99% (HPLC Verified)
- Form: Oxidised Form (NAD+)
- Target: Sirtuin Activation (SIRT1-7) & Mitochondrial ATP Production
- Solubility: Extremely High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 250mg Vial: Entry-level research aliquot.
- 500mg Vial: Standard High-Potency Vial.
- 1000mg (1g) Vial: Ultra-High Density.
- Vial Capacity: 10ml. (Note: These vials are larger than standard peptide vials to allow for greater dilution, which is critical for NAD+ research).
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms purity exceeds 99%.
- Endotoxin Controlled: Verified low endotoxin levels suitable for sensitive cell culture assays.
- Moisture Content: Strictly controlled via lyophilisation to prevent hydrolysis (degradation) of the dinucleotide structure.
Research Mechanism
In laboratory settings, NAD+ is utilised to investigate:
- Mitochondrial Biogenesis: The restoration of ATP output in senescent (aging) cells.
- Sirtuin Dependency: How NAD+ levels dictate the activity of SIRT1 and SIRT3, proteins that regulate inflammation and cell survival.
- DNA Repair: The consumption of NAD+ by PARP enzymes to repair strand breaks caused by radiation or oxidative stress.
- Addiction Models: Researching the role of NAD+ in neuro-restoration and craving reduction in dopamine-depleted pathways.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, IV infusion therapy, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE).
Storage: Store lyophilised vials in a cool, dry place (-20°C is best).
Scientific References
Cell Metabolism (2018) – "Therapeutic potential of NAD-boosting molecules: the in vivo evidence." (A comprehensive review of NAD+ vs precursors). View Article
Science (2013) – "Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging." (The landmark paper on why NAD+ drops with age). View Article
Trends in Biochemical Sciences (2014) – "NAD+ metabolism and the control of energy homeostasis." View Article
Nature Reviews Molecular Cell Biology (2007) – "Sirtuins: critical regulators at the crossroads between cancer and aging." View Article
