PT-141 (Bremelanotide) Peptide Information
- Chemical Name: Bremelanotide (cyclo-[Nle4, Asp5, D-Phe7, Lys10]-alpha-MSH-(4-10))
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 10mg vial
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
PT-141, scientifically known as Bremelanotide, is a synthetic cyclic heptapeptide. It is an active metabolite of Melanotan 2 but lacks the C-terminal amide group. Structurally, it is an analogue of the naturally occurring alpha-Melanocyte Stimulating Hormone (alpha-MSH).
In the research community, PT-141 is significant because of its mechanism of action. Unlike phosphodiesterase-5 (PDE5) inhibitors which act on the vascular system, PT-141 acts on the Central Nervous System (CNS), specifically targeting the hypothalamus.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, PT-141 is utilized to study the melanocortin system and its influence on neurobiological pathways.
Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:
- Melanocortin Receptor Agonism: PT-141 is a non-selective agonist of melanocortin receptors, showing high affinity for MC3R and MC4R. These receptors are densely populated in the Central Nervous System.
- CNS Signaling: Research focuses on how activation of MC4R in the paraventricular nucleus of the hypothalamus triggers downstream neural signaling related to appetitive behavior and arousal responses in animal models.
- Vascular vs. Neural Pathways: It is a key reagent for comparative studies distinguishing between peripherally acting agents (vascular) and centrally acting agents (neural) in physiological response models.
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the pharmacological profile, receptor affinity, and central nervous system effects of PT-141, please refer to the following literature:
British Journal of Pharmacology (2004) – Investigation into the receptor pharmacology of melanocortin agonists. click here to view the article
Annals of the New York Academy of Sciences (2003) – Research regarding the central melanocortin system and physiological regulation. click here to view the article
Neuropeptides (2005) – Study on the behavioral effects of MC4R agonists in rodent models. click here to view the article
