PT-141 (Bremelanotide) | 10mg

• PT-141 is a melanocortin peptide studied for libido signalling beyond skin-pigment pathways alone.
• Studies map it to melanocortin receptors in the central nervous system. Kisspeptin sits upstream of reproductive hormones, which is why the two are bundled.
• Mix the freeze-dried cake with bacteriostatic reconstitution solution (0.9% benzyl alcohol), keeping the stream off the powder. Unmixed vials keep for 12 to 24 months in a standard household fridge at 2°C–8°C, and the mixed vial stays in that same fridge.

Research trends often mention PT-141 (Bremelanotide) alongside phrases like arousal or libido in public search data. Current literature investigates these concepts strictly through cellular and molecular laboratory models, focusing on melanocortin receptor binding. Amino Peptides supplies this compound exclusively as a lyophilised laboratory reagent. Strictly for laboratory research.

• Agonistic binding at the melanocortin 4 receptor (MC4R) within isolated neural cell models.
• High-affinity interaction with the melanocortin 3 receptor (MC3R), modulating downstream cyclic AMP (cAMP) accumulation in cell-free systems.
• Transient engagement with MC1R, as observed in competitive radioligand binding experiments.
• Receptor subtype selectivity profiling indicates minimal cross-reactivity with MC2R and MC5R in stable transfected cell lines.

• Activation of the Gs-protein coupled receptor cascade, leading to the upregulation of adenylate cyclase activity in isolated cellular fractions.
• Subsequent elevation of intracellular cAMP levels, triggering protein kinase A (PKA) phosphorylation pathways.
• Modulation of intracellular calcium ion influx via voltage-gated channels in cultured neuronal models.
• Induction of immediate-early gene expression in controlled laboratory neurochemical models.

• 10mg Vial: Contains 10mg of lyophilised PT-141, providing a substantial yield for extensive cell culture assays and multi-phase receptor binding studies.

• HPLC Analysis: High-performance liquid chromatography ensures a purity level exceeding 99%, eliminating unwanted synthesis by-products.
• Mass Spectrometry: Confirms the exact molecular weight (1025.2 g/mol) and structural integrity of the cyclic peptide.
• Lyophilised Form: Processed into a stable, lyophilised solid to preserve molecular bonds during long-term laboratory storage.
• Endotoxin Testing: Rigorously screened to ensure endotoxin levels remain below 0.5 EU/mg, preventing interference in sensitive cellular assays.

• Acts as a non-selective agonist at melanocortin receptors, specifically targeting MC3R and MC4R in controlled cellular environments.
• Triggers intracellular signalling cascades, primarily activating adenylate cyclase to increase cyclic AMP (cAMP) levels within the cell.
• Modulates neurovascular cellular models by influencing nitric oxide synthase (NOS) pathways during in-vitro assays.
• Provides a highly stable molecular framework for evaluating receptor-ligand interactions and synaptic transmission models.

• Lyophilised (Freeze-Dried Vial): Stable at ambient room temperature during postal transit; store in a standard refrigerator (2–8°C) away from direct light for 12–24 months.
• Reconstituted (Liquid Solution): Store refrigerated at 2–8°C away from light. Using sterile bacteriostatic reconstitution solution (0.9% benzyl alcohol) preserves sterility across multiple draws while refrigeration maintains peptide integrity. Do not refreeze once mixed.

International Journal of Impotence Research: "Melanocortin receptor agonists in the laboratory evaluation of male and female sexual dysfunction" View Study

Expert Opinion on Investigational Drugs: "Bremelanotide for the laboratory evaluation of hypoactive sexual desire disorder" View Study

Peptides: "The melanocortin system and energy balance" View Study

Current Topics in Medicinal Chemistry: "Melanocortins and their receptors and antagonists" View Study

European Journal of Pharmacology: "Pharmacology of the melanocortin system" View Study