Sermorelin (GRF 1-29) Peptide Information
- Chemical Name: Sermorelin Acetate / GRF 1-29 (Growth Hormone Releasing Factor 1-29)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 5mg and 10mg variants
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview Sermorelin, also known scientifically as GRF 1-29, is a synthetic peptide analogue corresponding to the amino-terminal segment (amino acids 1–29) of the naturally occurring Growth Hormone Releasing Hormone (GHRH). Research has established that this specific 29-amino acid sequence is the shortest fragment of GHRH capable of possessing full functional activity in laboratory assays.
Unlike modified analogues (such as CJC-1295), Sermorelin retains the native structure of the hormone fragment. Consequently, it exhibits a very short biological half-life in plasma due to rapid enzymatic cleavage. This characteristic makes it a critical control in research studies investigating physiological, pulsatile hormone secretion versus sustained release mechanisms.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications In laboratory settings, Sermorelin is utilized to study the responsiveness of the anterior pituitary gland and the GHRH receptor (GHRH-R).
Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:
- Pituitary Stimulation: Sermorelin acts as a specific agonist of the GHRH receptor. It is used to stimulate the somatotroph cells in the anterior pituitary to secrete growth hormone.
- Pulsatile Secretion: Due to its rapid clearance (half-life of approx. 10-20 minutes in models), Sermorelin is used to mimic the body’s natural, episodic release of hormones, allowing researchers to study "pulse" signaling rather than continuous "bleed" signaling.
- Negative Feedback Loops: It serves as a tool to investigate the somatostatin-mediated negative feedback loops that regulate the endocrine axis.
Quality and Purity We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the pharmacological profile, receptor interaction, and structural properties of GRF 1-29, please refer to the following literature:
Journal of Clinical Endocrinology & Metabolism (1984) – Pharmacokinetic study of the GHRH(1-29) fragment. click here to view the article
Peptides (1986) – Analysis of the biological activity and stability of Growth Hormone Releasing Factor analogs. click here to view the article
Regulatory Peptides (1993) – Investigation into the receptor binding affinity of GHRH 1-29. click here to view the article
