Snap-8 (Acetyl Octapeptide-3) | 10mg & 100mg
Technical Specifications
- Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
- Chemical Name: Acetyl Octapeptide-3
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Target: SNARE Complex (SNAP-25 Protein)
- Mechanism: Neurotransmitter inhibition (Muscle relaxation)
- Solubility: High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 10mg Vial: Standard research aliquot.
- 100mg Vial: High-Density / Formulation Stock.
- Vial Capacity: 3ml.
- Note: This vial contains a significant amount of active material. It is designed for researchers preparing stock solutions for dilution or high-volume formulation studies.
Product Overview
Snap-8 (Acetyl Octapeptide-3) is a synthetic octapeptide that represents the next generation of "Botox-like" research agents.
It is an elongation of the famous peptide Argireline (Acetyl Hexapeptide-8). By adding two specific amino acids to the Argireline sequence, researchers engineered a molecule with significantly higher stability and affinity for the target.
The Mechanism:
Like Botulinum Toxin and Argireline, Snap-8 targets the SNARE complex—the cellular machinery required for neurons to release acetylcholine (the chemical that triggers muscle contraction). Snap-8 mimics the N-terminal end of the SNAP-25 protein, effectively "jamming" the complex. This prevents the vesicle from fusing with the membrane, inhibiting the release of neurotransmitters. The result is a reduction in muscle contraction intensity, making it the primary reagent for investigating the reduction of dynamic wrinkles and expression lines.
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 1075.2 Da) and the specific octapeptide sequence.
- TFA Removal: Processed via acetate exchange to ensure low cytotoxicity in dermal cell models.
Research Mechanism
In laboratory settings, Snap-8 is utilized to investigate:
- SNARE Complex Destabilization: Studies comparing the efficacy of octapeptides vs. hexapeptides in preventing vesicle fusion.
- Muscle Relaxation: In vitro assays measuring the reduction of glutamate and acetylcholine release in neuronal cultures.
- Anti-Wrinkle Efficacy: Researching the reduction of wrinkle depth caused by repetitive facial muscle contraction (dynamic lines).
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for direct consumer use as a finished cosmetic product. This is a concentrated raw material.
- Handling: Wear appropriate personal protective equipment (PPE).
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
International Journal of Cosmetic Science (2002) – "A synthetic hexapeptide (Argireline) with antiwrinkle activity." (The foundational research on the mechanism Snap-8 improves upon). View Article
Lipotec (Primary Manufacturer Data) – "SNAP-8: An elongation of the famous Argireline peptide." View Article
Dermatologic Therapy (2007) – "Cosmeceutical peptides." (Review of neurotransmitter-inhibiting peptides). View Article
Journal of Cosmetic Dermatology (2013) – "Topical peptides as cosmeceuticals." View Article
