Snap-8 (Acetyl Octapeptide-3) Peptide Information
- Chemical Name: Acetyl Octapeptide-3 / Acetyl Glutamyl Heptapeptide-3
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 10mg and 100mg variants
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption or Topical Use)
Product Overview Snap-8, chemically known as Acetyl Octapeptide-3, is a synthetic peptide consisting of eight amino acids. It is an elongated analogue of the hexapeptide Acetyl Hexapeptide-8 (Argireline).
The peptide is structurally designed to mimic the N-terminal end of SNAP-25, a protein that is a core component of the SNARE complex. In biochemical research, Snap-8 is a valuable tool for studying the mechanisms of neuronal exocytosis and the stability of the SNARE complex.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption, injection, or topical application on the skin.
Research Mechanism and Applications In laboratory settings, Snap-8 is utilized to investigate the modulation of neurotransmitter release via the synaptic vesicle fusion pathway.
Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:
- SNARE Complex Destabilization: Snap-8 competes with the native protein SNAP-25 for a position in the SNARE complex. By binding to the complex, it prevents the formation of a stable fusion pore, a critical step in vesicle docking.
- Inhibition of Exocytosis: Research focuses on the peptide’s ability to inhibit the release of neurotransmitters (such as acetylcholine and catecholamines) from the neuron to the muscle or target cell.
- Synaptic Transmission: It serves as a reagent to study the molecular machinery of synaptic transmission and the regulation of muscle contraction signaling pathways at the neuromuscular junction in in vitro tissue samples.
Quality and Purity We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a cosmetic, dietary supplement, or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the interaction with SNAP-25, SNARE complex biology, and experimental studies regarding Snap-8, please refer to the following literature:
International Journal of Cosmetic Science (2002) – Foundational study on the mechanism of peptide analogues in SNARE complex modulation. click here to view the article
Journal of Biological Chemistry (2005) – Research regarding the structural requirements for SNAP-25 inhibition. click here to view the article
Scientific Reports (2018) – Investigation into the efficacy of octapeptides in inhibiting neurotransmitter release in vitro. click here to view the article
