SS-31 (Elamipretide) | 10mg & 50mg
Technical Specifications
- Sequence: D-Arg-Dmt-Lys-Phe-NH2 (Tetrapeptide)
- Chemical Name: Elamipretide / Bendavia
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Target: Cardiolipin (Inner Mitochondrial Membrane Lipid)
- Mechanism: Electron Transport Chain Optimization & ROS Prevention
- Solubility: Extremely High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 10mg Vial: Standard research aliquot.
- 50mg Vial: High-Concentration / Course Vial.
- Vial Capacity: 3ml.
- Note: The 50mg vial allows for higher-dose research protocols typically seen in mitochondrial efficiency studies.
Product Overview
SS-31, also known as Elamipretide, is a cell-permeable, synthetic tetrapeptide belonging to the Szeto-Schiller (SS) class of antioxidant peptides.
The "Mitochondrial Medic":
Unlike standard antioxidants (like Vitamin C) which scavenge free radicals after they are produced, SS-31 works upstream at the source of the problem. It selectively targets and binds to Cardiolipin, a unique phospholipid found exclusively in the Inner Mitochondrial Membrane (IMM).
Mechanism of Action:
Cardiolipin is the "glue" that holds the Electron Transport Chain (ETC) complexes together. In aging or stressed tissue, Cardiolipin oxidizes and the ETC falls apart, causing electron leakage (creating ROS) and a drop in ATP (energy). Research shows that SS-31 penetrates the mitochondria and stabilizes Cardiolipin, effectively "plugging the leak." This optimizes electron flow, restoring ATP production while simultaneously preventing the formation of toxic Reactive Oxygen Species.
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms the presence of the synthetic amino acid Dimethyltyrosine (Dmt), which is critical for the peptide's ROS-scavenging ability.
- TFA Removal: Processed via acetate exchange to ensure cellular viability in mitochondrial respiration assays.
Research Mechanism
In laboratory settings, SS-31 is utilized to investigate:
- Mitochondrial Rejuvenation: The restoration of bioenergetics in "aged" mitochondria (sarcopenia and cognitive decline models).
- Ischemia-Reperfusion: Landmark studies protecting heart and kidney tissue from damage during blood flow restoration (e.g., post-cardiac arrest models).
- Metabolic Efficiency: Researching the improvement of ATP generation without increasing oxidative stress.
- Heart Failure: Investigating the improvement of left ventricular function through direct mitochondrial support.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, anti-aging therapy, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE).
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Journal of the American College of Cardiology (2013) – "Mitochondrial targeting of Elamipretide (SS-31) improves left ventricular function." (Key cardiac research). View Article
British Journal of Pharmacology (2014) – "The mitochondria-targeted peptide SS-31 prevents renal ischemia-reperfusion injury." View Article
Aging Cell (2019) – "Mitochondrial targeted peptide restores bioenergetics in aged skeletal muscle." (Research on sarcopenia and aging). View Article
Antioxidants & Redox Signaling (2013) – "Mitochondrial Cardiolipin as a Target for Bioenergetic Rejuvenation." View Article
