GHRP-2 (Pralmorelin) | 5mg & 10mg
Technical Specifications
- Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
- Chemical Name: Pralmorelin (Growth Hormone Releasing Peptide-2)
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Endotoxin: <0.5 EU/mg (Suitable for sensitive in vitro assays)
- Solubility: High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 5mg Vial: Contains 5mg GHRP-2
- 10mg Vial: Contains 10mg GHRP-2
Product Overview
GHRP-2 (also known as Pralmorelin) is a synthetic hexapeptide belonging to the Growth Hormone Releasing Peptide (GHRP) family.
It acts as a potent, selective agonist of the Ghrelin/Growth Hormone Secretagogue Receptor (GHS-R1a). In comparative research studies, GHRP-2 has demonstrated a higher efficacy for stimulating growth hormone release than GHRP-6, while exhibiting a distinct pharmacological profile. Unlike Ipamorelin, which is highly selective, GHRP-2 is known in research literature to induce a mild increase in ACTH (cortisol) and prolactin levels, making it a valuable reagent for studying the hypothalamic-pituitary-adrenal (HPA) axis alongside somatotropic pathways.
This peptide is frequently utilized in "stacking" protocols with GHRH analogues (such as Mod GRF 1-29) to investigate synergistic signaling mechanisms.
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 817.9 g/mol) and amino acid sequence.
- TFA Removal: Processed via acetate exchange to remove inflammatory trifluoroacetic acid salts, ensuring high viability in sensitive cell culture applications.
Research Mechanism
In laboratory settings, GHRP-2 is utilized to investigate:
- GHS-R1a Activation: The binding affinity and signal transduction pathways initiated by ghrelin-mimetic peptides.
- Appetite Signaling: Research into the peptide's orexigenic (appetite-stimulating) properties via hypothalamic activation.
- Synergistic Release: Quantitative analysis of growth hormone secretion pulses when GHRP-2 is co-administered with GHRH analogues.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, diagnostic, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE) including gloves and safety eyewear.
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Journal of Endocrinology (1995) – "Growth hormone-releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men." (Investigating the orexigenic effects). View Article
Peptides (1997) – "GHRP-2: Biochemical and pharmacological characterization." (Foundational study on the peptide's structure and function). View Article
European Journal of Endocrinology (1995) – "Comparison of the growth hormone-releasing activity of GHRP-2 and GHRP-6." View Article
