Hexarelin | 2mg & 5mg
Technical Specifications
- Sequence: His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2
- Chemical Name: Hexarelin Acetate
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Endotoxin: <0.5 EU/mg (Suitable for sensitive in vitro assays)
- Solubility: High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 2mg Vial: Contains 2mg Hexarelin
- 5mg Vial: Contains 5mg Hexarelin
Product Overview
Hexarelin is a synthetic hexapeptide of the Growth Hormone Releasing Peptide (GHRP) family. Structurally similar to GHRP-6, it is chemically modified to be more stable and potent.
In research literature, Hexarelin is often cited as the most potent growth hormone secretagogue in the GHRP class, capable of inducing massive GH pulses in animal models. However, its research profile is distinct due to its unique binding affinity for the CD36 Receptor (a scavenger receptor involved in fatty acid metabolism and heart function), in addition to the standard Ghrelin receptor (GHS-R1a).
This dual-mechanism makes Hexarelin a primary reagent for investigating cardioprotection and ischemia-reperfusion injury, alongside standard somatotropic signaling.
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 887.0 g/mol) and amino acid sequence.
- TFA Removal: Processed via acetate exchange to remove inflammatory trifluoroacetic acid salts, ensuring high viability in sensitive cell culture applications.
Research Mechanism
In laboratory settings, Hexarelin is utilised to investigate:
- CD36 Pathway: The non-hormonal, cytoprotective effects mediated by the CD36 receptor, specifically in cardiac tissue models (heart muscle cells).
- Desensitisation Kinetics: Researching the rapid attenuation (downregulation) of the GH response with chronic exposure, a characteristic unique to Hexarelin compared to Ipamorelin.
- Maximal Secretion: Studies aiming to test the upper physiological limits of pituitary growth hormone output.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, diagnostic, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE) including gloves and safety eyewear.
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Journal of Endocrinology (1998) – "Hexarelin, a synthetic growth hormone-releasing peptide, protects the rat heart from ischemia-reperfusion injury." (The landmark CD36/Cardio study). View Article
Peptides (2004) – "Cardiovascular actions of growth hormone secretagogues and ghrelin." (Review of the non-hormonal pathways of Hexarelin). View Article
European Journal of Pharmacology (1994) – "Pharmacological characterization of the specific binding of Hexarelin to pituitary membranes." View Article
