Product Overview
KLOW BLEND | 80mg (GHK-Cu 50mg, BPC-157 10mg, TB500 10mg, KPV 10mg)
KLOW BLEND is an advanced, quad-compound research reagent formulated strictly for in vitro and animal model studies. By incorporating a precise ratio of four extensively researched peptides into a single lyophilised vial, this complex allows investigators to observe a broad spectrum of cellular events simultaneously. It serves as an excellent substrate for testing extracellular matrix (ECM) remodelling, angiogenic upregulation, and the modulation of cellular inflammatory pathways under induced stress.
The formulation combines Glycyl-L-histidyl-L-lysine copper(II) (GHK-Cu), Body Protection Compound-157 (BPC-157), Thymosin Beta-4 derivative (TB500), and the naturally occurring alpha-MSH cleavage derivative, KPV. In laboratory settings, testing these specific compounds together provides a robust framework to monitor fibroblast migration alongside cytokine downregulation.
Technical Specifications
- Compound 1: GHK-Cu (50mg) | Copper-binding tripeptide
- Compound 2: BPC-157 (10mg) | Pentadecapeptide (Gastric derivative)
- Compound 3: TB500 (10mg) | Synthetic Actin-sequestering peptide
- Compound 4: KPV (10mg) | Alpha-MSH cleavage derivative (Lys-Pro-Val)
- Total Peptide Content: 80mg
- Format: Lyophilised Solid (Sealed Vial)
- Appearance: Pale blue crystalline powder (due to Copper II ion complex)
- Grade: Laboratory / Analytical Grade
- Purity: >99% (HPLC Verified across all four sequences)
Research Mechanism (Mechanism of Action)
Cellular models show this blend operating across four distinct, synergistic pathways:
- Cytokine Modulation (KPV): KPV acts intracellularly to inhibit the activation of the NF-κB pathway. In in vitro inflammatory models, this tripeptide consistently downregulates the expression of pro-inflammatory cytokines, allowing researchers to study cellular homeostasis and immune pathway modulation.
- ECM Remodelling (GHK-Cu): GHK-Cu modulates matrix metalloproteinases (MMPs). Laboratory assays repeatedly demonstrate its ability to stimulate fibroblast-driven synthesis of collagen and elastin while promoting the breakdown of irregular scar tissue structures.
- Angiogenic Upregulation (BPC-157): This pentadecapeptide rapidly upregulates Vascular Endothelial Growth Factor (VEGF) expression. When applied to in vitro endothelial models, BPC-157 accelerates the formation of new blood vessels, creating the nutrient pathways necessary for cellular proliferation.
- Cytoskeletal Motility (TB500): TB500 binds directly to cellular actin. By sequestering actin monomers, the peptide facilitates rapid cell migration and survival. This mechanism allows researchers to map accelerated tissue responses in varying testing environments.
Reconstitution & Handling Guidelines
Because of the highly concentrated peptide mass (80mg) and the inclusion of the copper ion complex, reconstitution must be handled methodically to avoid shearing the peptide bonds:
- Recommended Solvent: Bacteriostatic Reconstitution Solution (0.9% Benzyl Alcohol).
- Procedure: Inject the solvent slowly against the inner wall of the vial rather than directly onto the powder bed. Do not shake the vial. Roll it gently in a circular motion. Due to the high yield, allow extra time for the lyophilised solid to dissolve entirely into a clear, slightly blue-tinted liquid.
- Storage: Store the unmixed vial at -20°C. Once reconstituted, refrigerate at 2°C to 8°C and utilise promptly to maintain peptide stability.
WARNING: This product is intended for Laboratory Research Purposes Only. It is not intended for human consumption, diagnostic, or therapeutic use.
Scientific References (External Links)
For researchers seeking primary literature on the mechanisms described above:
Journal of Investigative Dermatology: “Alpha-Melanocyte-stimulating hormone and its cleavage product (KPV) downregulate inflammatory responses” View Study
Biomedical Research International: “GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration” View Study
Journal of Physiology and Pharmacology: “BPC 157 and blood vessels” View Study
Annals of the New York Academy of Sciences: “Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues” View Study
