MGF (Mechano Growth Factor) Peptide Information
- Chemical Name: Mechano Growth Factor (IGF-1Ec)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 2mg vial
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview
Mechano Growth Factor (MGF), scientifically identified as IGF-1Ec, is a splice variant of the Insulin-like Growth Factor-1 (IGF-1) gene. It is distinguished from the systemic liver-derived IGF-1 (IGF-1Ea) by its unique C-terminal E-domain sequence.
In biological systems, MGF expression is mechanically sensitive, meaning its gene is upregulated in tissue in response to mechanical stress or damage. This makes it a crucial subject of study for researchers investigating the localized, autocrine/paracrine responses to tissue loading.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications
In laboratory settings, MGF is utilized to study the initial phases of cellular repair and myogenesis. Unlike systemic IGF-1, which is primarily involved in the differentiation phase, MGF is researched for its role in the activation and proliferation of satellite cells (muscle stem cells).
Key areas of biochemical investigation include:
- Satellite Cell Activation: MGF is used to investigate the "kick-start" mechanism of the repair process, specifically how quiescent satellite cells are activated to re-enter the cell cycle.
- Neuroprotection Studies: Research explores the expression of MGF in neuronal tissues following ischemia, investigating its potential role in protecting neurons independent of IGF-1 receptors.
- Splice Variant Analysis: Studies focus on the alternative splicing mechanism of the IGF-1 gene, comparing the biological half-life and signaling stability of MGF (IGF-1Ec) versus systemic IGF-1 (IGF-1Ea).
Quality and Purity
We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling
WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the splicing mechanisms, satellite cell interaction, and experimental studies regarding MGF, please refer to the following literature:
FEBS Letters (1999) – The foundational study identifying the MGF splice variant and its expression in response to mechanical stimulation. click here to view the article
Journal of Physiology (2010) – Research into the role of MGF in muscle satellite cell activation and proliferation. click here to view the article
Neuroscience (2009) – Investigation into the neuroprotective effects of MGF in ischemic injury models. click here to view the article
