Selank (Tuftsin Analogue) | 5mg
Technical Specifications
- Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (Heptapeptide)
- Chemical Name: Tuftsin Analogue 7
- Format: Lyophilised Cake/Powder
- Purity: >99% (HPLC Verified)
- Stability: Enhanced enzymatic stability (vs. natural Tuftsin)
- Solubility: High (Aqueous)
- Solvent: Solvent not included (Sold Separately)
- Grade: Analytical Research Grade
Variant Breakdown
- 5mg Vial: Contains 5mg Selank.
- Vial Capacity: 3ml.
Product Overview
Selank is a synthetic heptapeptide and a structural analogue of Tuftsin, a naturally occurring immunomodulatory peptide produced by the spleen.
While Tuftsin plays a key role in the immune system, Selank was engineered with the addition of a specific amino acid sequence (Pro-Gly-Pro) at the C-terminus. This modification significantly improves its metabolic stability and allows it to modulate the Central Nervous System (CNS).
In research literature, Selank is unique for its "Regulartory" profile. Unlike direct GABA agonists (which can be sedating), Selank is investigated for its ability to normalise levels of serotonin, dopamine, and norepinephrine in the brain, while simultaneously inhibiting the enzymes responsible for the degradation of enkephalins (the body's natural painkillers).
Quality Assurance
This compound has undergone rigorous third-party analysis.
- HPLC Verified: Independent analysis confirms peptide purity exceeds 99%.
- Mass Spectrometry: Confirms accurate molecular weight (approx. 751.9 Da).
- TFA Removal: Processed via acetate exchange to remove inflammatory trifluoroacetic acid salts, ensuring high viability in sensitive cell culture models.
Research Mechanism
In laboratory settings, Selank is utilised to investigate:
- GABAergic Modulation: The peptide's allosteric modulation of GABA(A) receptors, potentially influencing anxiety-like behaviors in animal models without sedation.
- BDNF Expression: Research into the upregulation of Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus, a key marker for neuroplasticity and memory retention.
- Enkephalinase Inhibition: The mechanism by which Selank extends the half-life of endogenous enkephalins, modifying pain perception and stress response.
- Immunomodulation: Studying the conserved effects of the Tuftsin fragment on macrophage activity and IL-6 expression.
Safety and Handling
WARNING: This product is exclusively for laboratory research and in vitro use.
- Research Only: Not intended for human consumption, diagnostic, or therapeutic use.
- Handling: Wear appropriate personal protective equipment (PPE).
Storage: Store lyophilised vials in a cool, dry place. For long-term preservation, freezing at -20°C is recommended.
Scientific References
Bulletin of Experimental Biology and Medicine (2008) – "Semax and Selank inhibit the enkephalin-degrading enzymes of human serum." (Key study on the mechanism of action). View Article
Behavioural Brain Research (2016) – "Peptide Selank enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats." (Investigation into GABAergic synergy). View Article
Frontiers in Pharmacology (2018) – "Regulation of the Expression of BDNF and its Receptors in the Rat Hippocampus by the Anxiolytic Peptide Selank." View Article
Journal of Evolutionary Biochemistry and Physiology (2002) – "Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders." (Highlighting the Tuftsin/Immune connection). View Article
