Product Overview
Semax is a synthetic heptapeptide derived from adrenocorticotropic hormone (ACTH), specifically functioning as an ACTH (4-10) analogue. It is prominently utilised in laboratory research to investigate neurotrophic signalling pathways, cognitive modulation, and cellular survival mechanisms within in vitro and animal models.
This compound undergoes rigorous analytical testing to ensure structural integrity for research applications. Each batch is synthesised and purified to exceed standard laboratory requirements, providing researchers with reliable baseline data for cellular assays, receptor-binding investigations, and neurochemical profiling.
Technical Specifications
- Chemical Name: L-Methionyl-L-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular Formula: C39H54N10O10S
- Molecular Weight: 814.9 g/mol
- Target: Melanocortin receptors / TrkB receptor (BDNF signalling)
- Mechanism: Modulation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) expression
- Half-Life: ~15-30 minutes
- Format: Lyophilised Solid
- Appearance: White crystalline powder
- Grade: Laboratory / Analytical Grade
- Purity: >99% HPLC Verified
Variant Breakdown
- 5mg Lyophilised Vial
- Closure: Rubber stopper with flip-off aluminium seal.
Research Mechanism (Mechanism of Action)
- Neurotrophin Upregulation: Semax interacts with targeted biological systems to significantly elevate the expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in the basal forebrain and hippocampus of animal models.
- Receptor Signalling: The peptide modulates the TrkB receptor pathway, enhancing the binding affinity and efficacy of endogenous neurotrophins. This initiates intracellular signalling cascades critical for mapping synaptic plasticity.
- Cellular Survival Pathways: By upregulating specific neurotrophic factors, Semax is observed to inhibit apoptotic pathways in cellular models subjected to metabolic or oxidative stress, promoting overall structural integrity in neural architectures.
Safety, Handling & Reconstitution
Accurate reconstitution is required to maintain peptide stability. Utilise Bacteriostatic Reconstitution Solution (0.9% Benzyl Alcohol) for optimal dissolution. Store the lyophilised solid at -20°C. Once reconstituted, the solution must be stored between 2°C and 8°C. This material is strictly for Laboratory Research Purposes Only.
Scientific References (External Links)
Neuroscience Letters: “The effects of the synthetic peptide Semax on the expression of neurotrophin genes in the rat brain” View Study
Peptides: “Semax, an analogue of ACTH(4-10), with cognitive-enhancing activity” View Study
Journal of Molecular Neuroscience: “Semax modulates the expression of genes related to the vascular system in ischemic rat brain” View Study
Bulletin of Experimental Biology and Medicine: “Effect of Semax on the survival of neurons in conditions of severe oxidative stress” View Study
