TB-500 (Thymosin Beta-4) Peptide Information

Chemical Name: Thymosin Beta-4 (Tβ4)
Common Name: TB-500
Format: Lyophilised Powder (Vial)
Concentration: Available in 5mg and 10mg variants
Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
Purity: High Purity (>98%)
Grade: Research Grade (Not for Human Consumption)

Product Overview TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4). Endogenous Tβ4 is a ubiquitous actin-sequestering protein found in high concentrations in blood platelets, wound fluid, and various tissues.

In the field of biochemistry, this peptide is primarily recognized for its role in regulating the polymerization of actin, a protein essential for cell structure and movement.

This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.

Research Mechanism and Applications In laboratory settings, TB-500 is utilized to investigate cell motility, cytoskeletal organization, and vascular development.

Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:

Actin Sequestration: The primary mechanism of TB-500 is its ability to bind to monomeric G-actin (globular actin). This sequestration prevents polymerization into F-actin filaments, maintaining a pool of actin monomers vital for rapid cytoskeletal remodeling and cell migration.
Angiogenesis: Research explores the peptide's role in promoting the migration of endothelial cells and stimulating the formation of new blood vessels (angiogenesis), often by measuring the expression of Vascular Endothelial Growth Factor (VEGF).
Cell Migration: Studies focus on how Tβ4 influences the migration of keratinocytes and fibroblasts, key processes in the physiological response to tissue remodeling in in vitro assays.

Quality and Purity We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.

Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.

Safety and Handling WARNING: This product is a research chemical.

Keep out of reach of children.
Not for human use. This product is not a dietary supplement or drug.
Store in a cool, dry place away from direct sunlight.
Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.

Scientific References

For detailed data on actin sequestration, cytoskeletal dynamics, and the biochemical properties of Thymosin Beta-4, please refer to the following literature:

Vitamins and Hormones (2016) – Comprehensive review of the structure and function of Thymosin Beta-4. click here to view the article

Journal of Cell Science (2014) – Research detailing the mechanism of actin sequestration by Thymosin Beta-4. click here to view the article

Annals of the New York Academy of Sciences (2007) – Investigation into the biological activities of Thymosin Beta-4 in vascular development. click here to view the article