Tesamorelin (GHRH Analogue) Peptide Information
- Chemical Name: Tesamorelin (trans-3-hexenoyl-GHRH(1-44)NH2)
- Format: Lyophilised Powder (Vial)
- Concentration: Available in 2mg, 5mg, 10mg, and 20mg variants
- Inclusions: Includes 1 x 3ml vial of Bacteriostatic Water (solvent for reconstitution)
- Purity: High Purity (>98%)
- Grade: Research Grade (Not for Human Consumption)
Product Overview Tesamorelin is a synthetic analogue of the Growth Hormone Releasing Hormone (GHRH). Structurally, it consists of the full 44-amino acid sequence of human GHRH, modified with a trans-3-hexenoic acid group at the N-terminus.
This N-terminal modification serves a critical biochemical function: it enhances the peptide's resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-IV). This results in a significantly extended biological half-life and greater stability in plasma compared to native GHRH, making it a valuable tool for studying sustained pituitary stimulation.
This product is strictly intended for laboratory research and in vitro use only. It is not a medicine, food, or cosmetic product and is not intended for human consumption or injection.
Research Mechanism and Applications In laboratory settings, Tesamorelin is utilized to investigate the regulation of the somatotropic axis and lipid metabolism.
Researchers utilizing this peptide in controlled experimental models investigate the following biological mechanisms:
- Pituitary Agonism: Tesamorelin binds to GHRH receptors in the anterior pituitary gland, stimulating the synthesis and release of growth hormone.
- Lipid Metabolism: Research focuses on the downstream effects of this stimulation, specifically measuring changes in lipolysis (fat breakdown) and the reduction of visceral adipose tissue in animal models.
- IGF-1 Pathway: It serves as a potent reagent for studying the GH/IGF-1 axis, allowing researchers to observe the elevation of Insulin-like Growth Factor 1 (IGF-1) levels in a controlled, dose-dependent manner.
Quality and Purity We adhere to stringent manufacturing standards to provide researchers with a consistent and reliable product.
- Rigorous Testing: This product possesses a purity of >98% as verified via High-Performance Liquid Chromatography (HPLC).
- Molecular Verification: The molecular mass has been confirmed via Mass Spectrometry (MS).
- Contaminant Free: This product has been rigorously tested and confirmed to be free from heavy metals and bacterial contaminants.
- Solvent Included: Each order includes a 3ml vial of Bacteriostatic Water containing 0.9% Benzyl Alcohol, provided strictly as a solvent for laboratory reconstitution and solubility testing.
Safety and Handling WARNING: This product is a research chemical.
- Keep out of reach of children.
- Not for human use. This product is not a dietary supplement or drug.
- Store in a cool, dry place away from direct sunlight.
- Please refer to our 'Storage and Reconstitution' section for instructions on maintaining optimal product integrity and results.
Scientific References
For detailed data on the N-terminal modification, pharmacokinetics, and lipid metabolism effects of Tesamorelin, please refer to the following literature:
Journal of Clinical Endocrinology & Metabolism (2010) – Study on the effects of Tesamorelin on visceral fat and metabolic factors. click here to view the article
HIV Medicine (2013) – Research investigating the long-term safety and efficacy of GHRH analogues in metabolic regulation. click here to view the article
Peptides (2015) – Analysis of the structural stability and receptor binding affinity of hexenoyl-modified peptides. click here to view the article
